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8 13 He described it as "nonobstructive saccular or fusiform multifocal segmental dilatation of the intrahepatic bile ducts basically, he observed cavernous ectasia in the biliary tree causing a chronic, often life-threatening hepatobiliary disease.Portal hypertension may be present, resulting in other conditions including splenomegaly, hematemesis, and melena.
Province of Carolina, a British colonial province until 1729.9 Commonly, the disease is limited to the left lobe of the liver.