Adverse Reactions Occurring At An Incidence Of 2 Or More Among emsam-Treated Patients Table 2 enumerates adverse reactions that occurred at an incidence of 2 or more (rounded to the nearest percent) among 817 MDD patients treated with emsam in doses ranging from.If the patch becomes loose, press it back in place.Contraindications contraindications emsam (selegiline transdermal system) is contraindicated with selective serotonin reuptake inhibitors (ssris,.g., fluoxetine, sertraline, and paroxetine serotonin and norepinephrine reuptake inhibitors (snris,.g., venlafaxine and duloxetine the tricyclic antidepressants clomipramine and imipramine, the opiate analgesics meperidine, tramadol, methadone, pentazocine, and propoxyphene; and.

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Use of emsam with these drugs is contraindicated see contraindications and warnings AND precautions.Some products that may interact with selegiline include: antidepressants (including bupropion, maprotiline, mirtazapine other MAO inhibitors ( isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, tranylcypromine appetite suppressants (such as diethylpropion drugs for attention deficit disorder (such as atomoxetine, methylphenidate apraclonidine, buspirone, carbamazepine.The incidence of systemic tumors was not increased and the high dose provided systemic exposures to selegiline and its three metabolites in mice that were greater than 40 times the exposures in humans at the maximum recommended human dose (mrhd).

Adverse Reactions Leading To Discontinuation Of Treatment Among 817 MDD patients treated with emsam at doses of either 3 mg per 24 hours (151 patients 6 mg per 24 hours (550 patients) or 6 mg per 24 hours, 9 mg per 24 hours, and.Consequently, the degree of drug absorption may be 1/3 higher than the average amounts of 6 mg to 12 mg per 24 hours.